本书在介绍疼痛基本机理最新发现的同时讲授疼痛的基本理论，是以最新进展为基础的教材，并注重介绍应用疼痛模型研究神经科学机理和介绍神经科学的最近进展在疼痛研究中的应用。本书与以经典的疼痛路径知识为基础的论著显著不同，力图按照相关研究领域的最新进展，将以分子、突触和系统为理论基础的研究方法建立起来。本书每章均由在该领域有显著贡献的专家撰写，并经2－3名同行专业阅读以保证其内容有较强的可读性。

本书的读者对象为：高年级大学生、研究生、研究人员，医师、护士专业的学生以及临床疼痛科的医生。

Major Contributors

Preface

The Guide to Use This Book

Part Ⅰ Genes，Neurons and Neurotransmission

 Chapter 1 Genes and Neurons

 Chapter 2 Synapses：Coupling of Presynaptic Voltage-gated Ca2+ Channels to Vesicular Release of Neurotransmitter

 Chapter 3 Synaptic Vesicle Cycle at Nerve Terminals

Part Ⅱ Glutamate，Excitatory Transmission and Pain

 Chapter 4 Postsynaptic Excitatory Transmission

 Chapter 5 Kainate Receptors

 Chapter 6 Excitatory Amino Acid Neurotransmitter Regulation

 Chapter 7 Spinal Glutamate Receptors

 Chapter 8 Glutamate Kainate Receptor in Pain Transmission and Modulation

Part Ⅲ Neuropeptides，ATP,Retrograde Messengers and OpiOids

 Chapter 9 Neuropeptides

 Chapter 10 ATPandItsReceptorsinPain

 Chapter 11 Opioid Receptors

 Chapter 12 Retrograde Messengers

Part Ⅳ Inhibitory Transmission and Plasticity

 Chapter 13 Inhibitory Transmission

 Chapter 14 Plastic@of Inhibition；GABA／glycine Systems

Part Ⅴ Postsynaptic Signaling and Gene Regulation

 Chapter 15 Protein Kinases and Phosphatases

 Chapter 16 Activity-dependent Gene Regulation： How Do SynapsesTalktotheNucleusand Fine-tune Neuronal Outputs?

 Chapter 17 Second Messenger Pathways in Pain

 Chapter 18 Genetic Approaches for the Study of Pain

Part Ⅵ Peripheral Nocieeptor,Amygdala and Fear

 Chapter 19 Peripheral Nociceptors

 Chapter 20 Amygdala-Pain Processing and Pain Modulation

 Chapter 21 Fear Learning

Part Ⅶ Spinal Plasticity,Reorganization and Chronic Pain

 Chapter 22 Silent Glutamatergic Synapses and Long-term Facilitation in Spinal Dorsal Horn Neurons

 Chapter 24 Spinal Microglia in Neuropathic Pain

Plasticity

Part Ⅷ Cortical Plasticity,Reorganization and Amputation

 Chapter 25 ACC Plasticity

 Chapter 26 Reorganization of the Sensorimotor System after Injury

Part Ⅸ Endogenous Analgesia and Other Form of Analgesia

 Chapter 27 Endogenous Biphasic Modulation

 Chapter 28 Paradoxical Analgesic and Hyperalgesic Efrects of Stress

 Chapter 29 Acupuncture Analgesia

 Chapter 30 Mechanisms of Opioid Tolerance

Part Ⅹ Models for Studying Pain and Searching for Pain Killers

 Chapter 31 Models in Pain Research

 Chapter 32 Models for Studying Pain and Searching for Pain Killers in Vitro Electrophysiological Studies ofPain

 Chapter 33 Whole-cell Patch-clamp Recording in Vivo

 Chapter 34 Basic Mechanisms of ClinicaUy Used Drugs

Selected References

Appendix Ⅰ Units in Pain Reaearch

Appendix Ⅱ Useful Wlebsites for the Study of Pain

Appendix Ⅲ List of Scientific Journals Publishing Studies in Pain

Appendix Ⅳ Fundamental and Innovative Contribution to Understanding of Basic Mechanism of Pain，Analgesia and Persistent Pain