本书从生物材料的角度对转化医学的发展热点和方向进行全面和系统的阐释，并对处于转化医学前沿的生物材料研发现状和进展、基本性质及其应用实例和效果进行系统论述。
本书不仅适合生物材料和转化医学领域的研究人员和技术人员阅读，也可作为高等院校相关专业本科生、研究生的教材或参考书。

杨磊教授，河北工业大学（天津）生命科学与健康工程学院院长，国际骨转化医学联合研究中心（IRCTO）副主任，曾任苏州大学骨科研究所副所长。清华大学材料科学与工程学士、硕士，美国布朗大学工程学博士、创新与创业管理学硕士。主要研究方向为骨科医疗器械，生物材料在骨科及转化医学领域的应用。

List of Contributors
Foreword
Preface
1 Translational medicine and biomaterials: Basics and relationship Amit K. Roy, Akhenaton-Andrew D. Jones, III and Thomas J.Webster
1.1 Overview of biomaterials in translational medicine
1.2 Fundamentals of translational medicine
1.2.1 Definitions
1.2.2 Challenges
1.2.3 Ethics
1.2.4 Education
1.3 Fundamentals of biomaterials science
1.3.1 Biomaterials and orthopedics
1.3.2 Hydrogels as biomaterials
1.3.3 Infectious disease control and biomaterials
1.3.4 Biomaterials for neurological disorders and neuroregeneration
1.3.5 Biomaterials for cancer
1.3.6 Biomaterials and teeth
1.3.7 Nanotechnology and picotechnology as biomaterials
1.3.8 Biomaterials as sensors
1.3.9 Biomaterials for drug delivery
1.3.10 Biomaterials and 3D printing
1.3.11 Biomaterials and stem cells
1.4 The role of biomaterials in translational medicine
References
2 Regulatory aspects of medical devices and biomaterials Prabaha Sikder and Sarit B. Bhaduri
2.1 Introduction
2.2 Terminology
2.3 Basic pathways to medical device approval
2.3.1 Pre marketing notification: the 510(k) application
2.3.2 Premarket approval
2.3.3 The humanitarian device exemption
2.4 Comparison and contrasts between the various pathways
2.5 Postapproval follow-up for devices
2.6 Comparison with EU approval protocols of devices
2.7 Summary
References
3 The translatory aspects of calcium phosphates for orthopedic applications Huan Zhou and Sarit B. Bhaduri
3.1 Brief introduction of calcium phosphates
3.2 Orthopedic implant coating
3.2.1 The translatory aspects of calcium phosphate orthopedic coatings
3.2.2 Porosity and roughness
3.2.3 Adhesion strength
3.2.4 Crystallinity
3.2.5 Surface chemistry
3.3 Synthetic bone grafts
3.3.1 The translatory aspects of calcium phosphate bone grafts
3.3.2 Porosity and interconnectivity
3.3.3 Phase composition
3.3.4 Mechanical strength
3.4 New trends
3.4.1 Carriers for active agents
3.4.2 Three-dimensional-printing
3.5 Conclusions
References
4 Cardiovascular engineering materials in translational medicine Weihua Song, Bae Hoon Lee, Lay Poh Tan and Huaqiong Li
4.1 Introduction
4.2 The replacement of cardiovascular system using engineered biomaterials
4.2.1 Valves
4.2.2 Vascular grafts
4.3 Injectable materials and their applications for cardiac repair and regeneration
4.3.1 Injectable hydrogels
4.3.2 Natural materials
4.3.3 Synthetic materials
4.3.4 Hybrid materials
4.4 Discussion and concluding remarks
References
5 Delivery systems for biomedical applications: Basic introduction, research frontiers and clínical translations
Changlu Xu, Varun Sivarajan Thiruvadi, Rachel Whitmore and Huinan Liu
5.1 Introduction
5.2 Biological cargos utilized in delivery systems
5.2.1 Types of biological cargos
5.2.2 Approaches and mechanisms of cargo loading
5.3 Mechanism for cargo delivery
5.3.1 Passive delivery
5.3.2 Active delivery
5.4 Research frontiers of delivery systems
5.4.1 Development trends of delivery systems
5.4.2 Current emphasis of delivery systems
5.5 Clinical translation of delivery systems
5.5.1 Oral delivery systems
5.5.2 Nanoparticles and liposomes
5.5.3 3D scaffolds and implants
5.6 Conclusions
References
6 Biomaterials and scaffolds for the treatment of spinal cord injury Xiaoxiao Wen, Saijilafu, Zongping Luo, Huilin Yang, Weihua Wang and Lei Yang
6.1 Introduction
6.2 Electrospun scaffolds
6.2.1 Electrospun scaffolds with aligned structures
6.2.2 Establishing 3D fibrous guidance channels
6.2.3 Incorporation of bioactive components
6.3 Self-assembling peptide scaffolds
6.4 Scaffolds based o