The clinical laboratory has long functioned as a dynamic environment in which new technologies constantly challenge us by their implementation in new diagnostic tests.With the clinical laboratory is now challenged by yet another technological advancement,sis of nucleic acids……

Preface

List of Contributors

Part I Basic Molecular Biology

1 A Historical Perspective on the Clinical Diagnostic Laboratory

2 An Overview of Nucleic Acid Chemistry,Structure,and Function:The Foundations of  Molecular Biology

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Part II Molecular Technologies

4 Nucleic Acid Blotting Techniques:Theory and Practice

5 DNA Amplification Techniques:An Overview

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Part III Applications To Molecular Pathology

10 An Overview of Molecular Genetics

11 Genetic Basis of Neurologic and Neuromuscular Diseases

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Part IV Issues For The Clinical Molecular Pathology Laboratory

17 Quality Control Issues for the Clinical Molecular Pathologist

18 Prospects for the Future Role of the Clinical Laboratory

Genetic disorders account for a significant amount of human disease.About 4% of all infants born in the United States and Canada are affected by a birth defect.Approximately 1 in 200 births is affected by a chromosomal abnormality.